It happened around 4:00 Saturday evening on West Boonville-New Harmony Road near Gilles, in the Darmstadt area.
The Vanderburgh County Sheriff tells us a woman was driving east on Boonville-New Harmony when she drove off the road and into a guard rail.
She was wearing a helmet, but suffered serious injuries.
She was air lifted to St. Mary's Hospital where her condition is unknown.
Copyright 2017 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.