It happened around 4:00 Saturday evening on West Boonville-New Harmony Road near Gilles, in the Darmstadt area.
The Vanderburgh County Sheriff tells us a woman was driving east on Boonville-New Harmony when she drove off the road and into a guard rail.
She was wearing a helmet, but suffered serious injuries.
She was air lifted to St. Mary's Hospital where her condition is unknown.
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