Police say a man was driving motorcycle south on SR 65, near Weiss Rd, and veered off the road striking a guardrail.
The driver, 66 year-old Jeffrey Stevens, of Evansville, was ejected and landed in the roadway.
Deputies and Firefighters assisted Stevens until Life Flight arrived. Alcohol and/or drugs are not considered a factor in the crash at this time.
Deputies say Stevens was not wearing a helmet.