Th call came in around 2 Thursday morning off Doss Road and 62 West in Depoy.
Kentucky State Police say that 11 people were inside at the time and 2 were able to get out, the father and his 11-year-old daughter.
They were air lifted to Vanderbilt Medical Center in Nashville.
KSP says both are in stable but critical condition.
The mother and 8 of the children are confirmed dead.
No word yet on a possible cause.
PREVIOUS: The Muhlenberg County Coroner's Office has confirmed multiple deaths at a house fire in Depoy, Kentucky.
The call came in around 2 AM around Doss Road off Highway 62 West.
We have a crew on the scene and we'll updates on Daybreak from Western Kentucky Bureau Chief Mike Pickett.