Witnesses told authorities the juveniles, ages 9, 10, and 12, were seen leaving the scene of the fire on Walnut St.
Police questioned the three and have charged them with arson and criminal trespassing. All three have been released to their parents.
Greenville Police are still investigating the fire.
PREVIOUS: Firefighters from several departments are battling a large fire in Muhlenberg County tonight. This is a picture sent to us by Matt Perkins.
Four departments were called to Walnut St. in Greenville just before 7 p.m., where a vacant building is engulfed in flames.
Central dispatch tells us the building was once used by an old tobacco business. No report on any injuries or how the fire was started.
We'll continue to keep you updated.