As of October 1, the stores will no longer sell cigarettes. CVS operates 7,600 stores nationwide and more than 800 minute clinics.
The company's CEO says the choice to not sell tobacco is the right thing to do to keep their customers on a path to stay healthy.
The decision does come at a hefty price. CVS estimates an annual loss of $2 billion from tobacco shoppers.
A spokesperson for Walgreens says they will continue to review which products its customers want and did not say if they would make a similar move.