It happened on Kentucky 600, about two miles south of the town of Weir.
State Police say 33 year-old Cary Daugherty of Greenville came around a curve and slide into the oncoming lane striking 40 year-old Elizabeth Groves of South Carrollton.
Groves was taken to Madisonville's hospital. Daugherty was not hurt.
Police say both drivers were wearing their seatbelts.