It happened at US-45 and Barnett Street in Harrisburg. Saline County deputies assisted Harrisburg officers with the accident.
It is believed that a car was traveling northbound on US-45 and was trying to turn west onto Barnett Street when it turned into the path of a semi-truck.
The semi-truck hit the first car and pushed it about 90 feet into another car.
Two drivers were taken to the hospital for their injuries. The semi-truck driver refused treatment.
The driver's names have not been released.