It happened in the 7100 block of East State Road 64 near Saint Anthony.
According to News Now Dubois County, no one was home at the time the fire broke out. Several neighbors called 911 shortly after 11p.m. to report the fire.
A tanker truck and crew were called in to help put out the flames, which did considerable damage to the home.
No word yet on how the fire started, but dispatch says no one was hurt and no one inside the home when the fire broke out.