Zachary Parks and Leslie Osborn Jr. face charges of involuntary manslaughter in connection with the death of Timothy Stafford of Dubois.
Police say two other men got into a fight outside JR's bar early Saturday.
Parks and Osborn were apparently friends with one of the men, Stafford was a friend to the other.
Investigators say during the fight Stafford tried to intervene. That's when officials say Osborn and Parks started hitting him.
Stafford was unconscious when police arrived at the scene.
He later died at Saint Mary's Medical Center in Evansville.