The accident happened just before 5 p.m. Tuesday.
One of the cars was overturned, and at least one person was taken to the hospital with unknown injuries.
Crews are still on the scene cleaning debris and are urging drivers to use caution in the area.
Emergency responders are on scene of another accident in southern Vanderburgh County.
It happened along I-69 near the exit ramp to Highway 41 south. A crash involving four vehicles has closed one lane to traffic.
We’re told there are injuries, but no word yet on how many people are hurt.
Eyewitness News will continue to bring you updates.